In this episode, Dr. Anurag Singh joins Dave Asprey on The Human Upgrade to delve into the critical role of mitochondria in aging research, chronic inflammation, and the biology of immune system decline. Dr. Singh, a leading expert in medical research and cellular health, explores how mitochondria dysfunction drives immune aging and inflammaging, while sharing actionable wellness tips to boost longevity and promote aging gracefully.
Listeners will gain insights into how enhancing mitochondria health through interventions like fasting, postbiotics, and supplements can rejuvenate immune resilience and counteract age-related diseases. The episode discusses groundbreaking findings on compounds like Urolithin A, which improve mitochondrial efficiency, dampen inflammation, and support disease prevention. Practical advice is provided on optimizing cellular energy, reversing immune fatigue, and improving overall health and wellness.
Dr. Singh also highlights the link between nutrition, the immune system, and cellular regeneration, offering guidance on combining mitochondrial boosters with anti-inflammatory strategies and lifestyle adjustments. The conversation extends to skin health, exploring innovations in topical applications that enhance collagen synthesis, mitigate wrinkles, and repair photo-damaged skin.
For anyone curious about the intersection of nutrition and aging, healthcare, and cutting-edge strategies for chronic inflammation and immune system enhancement, this episode serves as a roadmap to living healthier and longer. Don’t miss the deep dive into actionable steps for longevity and the transformative science of mitochondria!
Resources:
• 2025 Biohacking Conference – https://biohackingconference.com/2025
• Timeline Nutrition – https://www.timeline.com/dave to get 10% off your first order
• Timeline Instagram – https://www.instagram.com/timeline_longevity/
• Dave Asprey’s Website – https://daveasprey.com
• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books
• Danger Coffee – https://dangercoffee.com
• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/
• Dave Asprey’s Linktree – https://linktr.ee/daveasprey
• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com
• Own an Upgrade Labs – https://ownanupgradelabs.com
• Upgrade Labs – https://upgradelabs.com
• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com
Timestamps:
• 00:00 Introduction to Longevity and Mitochondria
• 01:28 The Role of Mitochondria in Immune Health
• 03:36 Understanding Inflammaging and Immune Aging
• 07:47 Measuring Immune Health and Inflammation
• 13:33 Urolithin A: A Mitochondrial Booster
• 16:46 Dosage and Effects of Urolithin A
• 26:11 Urolithin A and Exercise Performance
• 28:31 Urolithin A for Skin Health
• 31:34 Collagen and Aging: The Role of MMPs
• 33:27 Personal Experience with MMPs and Recovery
• 35:04 Measuring MMPs and Their Impact on Longevity
• 36:18 Skin Health and Urolithin A
• 38:39 Exploring Urolithin A’s Broader Benefits
• 40:33 Brain Health and Urolithin A
• 43:33 Combining Supplements for Optimal Health
• 45:54 Omega-3s and Mitochondrial Health
• 46:51 Ketones, MCTs, and Urolithin A
• 54:30 Final Thoughts on MitoPure and Supplementation
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
Twitter: https://twitter.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
