Discover the groundbreaking science behind fasting mimetics and how they can help you unlock the full benefits of intermittent fasting without extended food deprivation. In this episode of the Human Upgrade, Dave Asprey sits down with Chris Rhodes, a leading researcher in longevity supplements, to discuss his innovative work on Mimio, a cutting-edge formula designed to replicate the biological effects of a 36-hour fast—without actually fasting.
Learn how Mimio activates key longevity pathways like autophagy, boosts NAD production, and enhances metabolic health optimization to extend lifespan by an astonishing 96% in model organisms. Chris explains the science behind fasting-related compounds such as PEA and OEA, which help with appetite suppression, testosterone optimization, and improving cognitive function. The conversation dives deep into the role of biohacking for longevity, comparing the effects of Mimio to well-known longevity supplements like metformin and rapamycin.
If you’re looking to maximize the benefits of intermittent fasting, improve metabolic health, and tap into the latest breakthroughs in big data in longevity, this episode is packed with actionable insights.
Don’t miss this in-depth conversation on the future of fasting mimetics and metabolic health optimization.
*** Get 20% off Mimeo at mimiohealth.sjv.io/3J9abX with code: DAVE ***
Sponsors:
Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Mimio Instagram – https://www.instagram.com/mimiohealth/
• Mimio Website: https://mimiohealth.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Chapters:
00:00 – Intro
00:58 – Fasting & Longevity
01:88 – Optimal Fasting Length
03:39 – Alternate Day Fasting: Pros & Cons
05:50 – Key Fasting Compounds
07:34 – Spermidine & Longevity Molecules
11:41 – FDA Roadblocks on Natural Compounds
15:37 – AI, Big Data & Longevity Research
31:19 – Mimeo’s Impact on Testosterone & Aging
35:16 – Longevity & Death Philosophy
36:48 – Biohacking Origins
37:03 – Metabolism & Cognitive Function
38:35 – Unexpected Effects of Fasting
40:43 – Fasting & Circadian Rhythms
43:09 – Mimeo Science & Benefits
45:14 – Mimeo in a Daily Routine
55:05 – Men vs. Women: Fasting Differences
01:02:23 – Future of Nutrition & Biohacking
01:07:21 – Conclusion & Discount Code
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
