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    Home » How to Control Your Sense of Pain & Pleasure | Huberman Lab Essentials

    How to Control Your Sense of Pain & Pleasure | Huberman Lab Essentials

    Mal AntoniBy Mal AntoniJune 19, 2025 All Videos 2 Mins Read
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    In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity.

    I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure.

    Episode show notes: https://go.hubermanlab.com/NiHdOrb

    Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/xmhsWAqP_0Y?si=uqKQb1YZDs4jb56I

    Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S

    *Follow Huberman Lab*
    Instagram: https://www.instagram.com/hubermanlab
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    LinkedIn: https://www.linkedin.com/in/andrew-huberman
    Website: https://www.hubermanlab.com
    Newsletter: https://www.hubermanlab.com/newsletter

    *Timestamps*
    00:00:00 Pain & Pleasure
    00:00:39 Skin, Appetitive vs Aversive Behaviors
    00:02:10 Skin, Neurons & Brain
    00:04:46 Brain Interpretation, Homunculus, Two-Point Discrimination Test
    00:07:43 Pain & Pleasure, Subjective Interpretation
    00:09:53 Tool: Pain & Expectation
    00:11:31 Pain Threshold
    00:13:09 Heat & Cold, Tool: Moving into Cold or Hot Environments
    00:15:00 Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine
    00:19:17 Acupuncture, Electroacupuncture, Pain Management
    00:22:07 Red Heads & Pain Threshold, Endorphins
    00:24:02 Improving Pain Threshold, Dopamine
    00:25:30 Pleasure, Dopamine, Serotonin; Depression, Anti-depressants
    00:29:41 Pleasure & Pain Balance, Dopamine, Addiction
    00:31:37 Recap & Key Takeaways

    Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

    Mal Antoni

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