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    Home » Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

    Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

    Mal AntoniBy Mal AntoniJuly 24, 2025 All Videos 2 Mins Read
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    In this Huberman Lab Essentials episode, my guest is ⁠Dr. Matthew Johnson, PhD⁠, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.

    We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.

    Episode show notes: https://go.hubermanlab.com/yjsDPfV

    Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/GzvzWO0NU50

    Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S

    *Follow Huberman Lab*
    Instagram: https://www.instagram.com/hubermanlab
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    LinkedIn: https://www.linkedin.com/in/andrew-huberman
    Website: https://www.hubermanlab.com
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    *Timestamps*
    00:00:00 Matthew Johnson; Psychedelics
    00:01:44 Different Classes of Psychedelics
    00:04:33 Psychedelics & Altering Models
    00:06:18 LSD, Psylocibin & Serotonin
    00:08:44 Psychedelic Clinical Trials
    00:12:28 Therapy, Trust, Psychedelics
    00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
    00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
    00:24:43 Dangers of Psychedelics
    00:27:04 Microdosing Psychedelics, Antidepressant
    00:31:20 Head Injuries, Psychedelics, Depression

    Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

    Mal Antoni

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