Many doctors still treat anxiety and depression with SSRIs, despite research showing depression isn’t caused by a serotonin deficiency. Dr. Gundry’s guest reveals that GABA deficiency may play a bigger role—and that better regulating your GABA system could be key to improving mood, sleep, and overall mental health.
Is a GABA deficiency the root cause of your anxiety? In this eye-opening episode, Dr. Gundry and his guest, Dr. Scott Sherr dive deep into the world of GABA, a crucial neurotransmitter that acts as the brain’s "brakes". We’ve all heard about dopamine and serotonin, but it’s the balance between glutamate and GABA that’s responsible for 80% of your brain’s neurotransmission. Learn why modern life, with its "hustle culture" and constant stimulation, is causing a widespread GABA deficiency. This deficiency can manifest as anxiety, stress, insomnia, and even depression.
Discover how a low GABA system leads to an overstimulated brain and why simply taking a GABA supplement might not be the answer. We’ll discuss why the supplement is often too large to cross the blood-brain barrier , and what a positive reaction to it could mean for your health. Instead, learn about the right ways to support your GABA system through diet, lifestyle, and a targeted "obligate pair strategy" of supplementation.
00:00 – The Role of GABA: The brain’s "brakes" and the glutamate balance.
02:18 – Modern Life and GABA Deficiency: The impact of hustle culture and cortisol.
05:01 – The Dopamine Connection: How dopamine hits deplete your GABA.
07:00 – How to Test for GABA Deficiency: Why direct testing doesn’t work and what to check instead.
11:00 – Debunking the Serotonin Myth: Why depression isn’t a serotonin deficiency.
15:00 – GABA vs. Gabapentin & Alcohol: The difference between natural and synthetic GABA enhancers.
18:00 – The Leaky Brain: Why taking a GABA pill might not work.
19:00 – Mocktails & GABA: Are kava and other herbs effective?.
22:00 – The Mushroom Connection: A powerful compound that supports GABA.
26:00 – Answering a Listener’s Question: What to look for in a GABA supplement.
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