AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.
Listen to the FULL-LENGTH version of this episode on your favorite audio platform:
-Apple: https://podcasts.apple.com/us/podcast/the-human-upgrade-biohacking-for-longevity-performance/id451295014
-Spotify: https://open.spotify.com/show/2mkB9OoukPVKCTKSuAIgCq
Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.
Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.
You’ll Learn:
• How digital twins will end human drug testing
• Why AGI could replace doctors and computer jobs within five years
• How AI models immune function, metabolism, and aging
• The role of mitochondria and inflammation in longevity
• How GLP-1 drugs and metformin extend lifespan
• What continuous biological monitoring means for health tracking
• How AI is transforming functional medicine and personalized care
• Why NAD and energy metabolism are key to human performance
They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.
This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.
This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, AGI, Human performance, Aging research, Immunology,
**Keep up with Derya’s work: https://x.com/derya_?lang=en
Timestamps:
00:00 — Trailer
01:22 — Intro
02:37 — AI and Longevity
04:16 — Regulation and Medicine
07:18 — Using AI for Health
11:52 — Escape Velocity
15:34 — AI Doctors
16:04 — Bad Data
18:47 — AI and Education
21:51 — Is College Worth It
25:49 — Reengineering Immunity
28:29 — Chronic Fatigue & Long COVID
30:40 — Key Immune Biomarker
33:02 — Longevity Protocol
37:05 — Diet & Glucose
37:41 — Metformin vs GLP-1
38:59 — NAD & Metabolism
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave’s favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Collective: https://www.ourupgradecollective.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
