You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tribal thinking that can plague modern health conversations!
Host Dave Asprey sits down with Dan Buettner for a rare co hosted podcast that explores where biohacking and Blue Zones philosophy clash and where they surprisingly align. Dan Buettner is a National Geographic Explorer, Emmy Award winning producer, and five time New York Times bestselling author. He is best known for identifying the Blue Zones, regions of the world where people live the longest and healthiest lives. His research has reshaped cities, healthcare systems, and insurance models across the United States, improving health outcomes for more than 10 million Americans. His Netflix series Live to 100: Secrets of the Blue Zones earned six Emmy nominations and won three. Dan is also an accomplished endurance athlete with three Guinness World Records in distance cycling.
Together, Dave and Dan debate the true limits of human lifespan, whether longevity is driven more by environment or intervention, and how modern tools like AI, functional medicine, supplements, fasting, ketosis, and sleep optimization compare to walkable communities, movement, and purpose. They explore mitochondria, neuroplasticity, metabolism, brain optimization, and why Smarter Not Harder applies whether you follow a carnivore leaning diet, a bean based diet, or something in between. This episode gives you both sides of the longevity argument and lets you decide what fits your biology, values, and goals.
You’ll Learn:
• Why Dan believes average human lifespan likely tops out in the mid 90s and how Blue Zones support longevity without chronic disease
• Why Host Dave Asprey believes biohacking, AI, and modern science could push longevity toward 150, 180, or beyond
• How environmental design hacks unconscious behavior more effectively than willpower
• The overlooked role of light, darkness, and circadian rhythm in sleep optimization and human performance
• How fasting and ketosis support longevity when used strategically instead of obsessively
• Why mitochondria signaling may matter more than fixing every cell individually
• How neuroplasticity and brain optimization influence aging and resilience
• Where supplements and nootropics help and where simplicity wins
• The real debate around carnivore diets, carbs, beans, metabolism, and longevity
• Why community, purpose, and movement remain foundational even in advanced biohacking
• How Danger Coffee fits into energy, focus, and Smarter Not Harder performance strategies
Thank you to our sponsors!
– BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.
– MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.
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– BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
Timestamps:
0:00 – Trailer
2:50 – Introduction to Dan Buettner
4:59 – Light & Circadian Biology
7:21 – Aging Science & Interventions
13:18 – Community & Social Connection
15:16 – Biohacking Basics
19:04 – Movement & Exercise
21:20 – Diet & Nutrition Philosophy
31:06 – Dave’s Daily Diet
33:49 – Salt & Hydration
41:07 – Marketing & Building Bulletproof
49:10 – Rapid Fire Round
55:00 – Closing Thoughts
Resources:
• Dan’s new podcast: https://danbuettner.com/podcast/
• Dan’s website: https://danbuettner.com/
• Dave Asprey’s Latest News | Go to https://daveasprey.com/ to join Inside Track today.
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave’s favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Collective: https://www.ourupgradecollective.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
