Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.
Show notes: https://go.hubermanlab.com/oBv3wjv
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Dr. Alex Marson
Lab website: https://www.marsonlab.org
Gladstone Institute: https://gladstone.org/people/alex-marson
USCF profile: https://profiles.ucsf.edu/alexander.marson
Publications: https://gladstone.org/people/alex-marson#publications
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LinkedIn: https://www.linkedin.com/in/alex-marson-65483a5
Timestamps
00:00:00 Alex Marson
00:02:21 Diseases & Current Biological Landscape; AI & Computational Tools
00:05:56 Immune System, Innate vs Adaptive Immune System
00:10:55 Thymus, T Cell Selection; B Cells & Antibodies
00:13:23 Sponsors: BetterHelp & Helix Sleep
00:16:11 Immune System Health, Sleep, Diet; Genes
00:20:56 Childhood Exposure & Allergy Prevention; Autoimmune Reactions
00:25:27 Whole Body Immune Response, Cytokines & Fever; Antibiotics
00:30:51 Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight
00:38:27 BRAC Mutations, Mutagens, Pesticides
00:42:33 Sponsor: AG1
00:43:57 X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye
00:49:34 Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy
00:59:04 CRISPR, Immunotherapies
01:02:52 Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet
01:08:27 CRISPR Discovery & Mechanism
01:17:06 CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution
01:20:57 Sponsor: LMNT
01:22:17 CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention
01:33:47 Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines
01:39:57 COVID Pandemic & Trust in Science, mRNA Vaccine
01:47:51 Sponsor: Function
01:49:39 Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets
01:55:45 CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity
02:05:42 Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience
02:10:44 Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function
02:17:55 Banking T Cells or iPSCs?, Future of Cell Programming
02:24:41 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
#HubermanLab #Science #Health
Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer
