Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women’s hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.
Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women’s health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women’s longevity today.
Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s.
You’ll Learn:
-Why vaginal hormone delivery outperforms every other delivery method for women
-How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear
-Why a carnivore or animal-based diet raises estrogen and why fiber lowers it
-How progesterone converts to testosterone in women, and why you may not need a testosterone prescription
-The real reason SSRIs get prescribed when hormone replacement therapy should come first
-Why iodine is essential for breast health, estrogen metabolism, and thyroid function
-How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys
-Why both partners need hormone replacement therapy for a relationship to thrive
-How hormones control mitochondria, dopamine, norepinephrine, and every system in your body
Resources:
• Visit Sarah’s Website and use code ‘PODCASTDRSARAH’: https://www.innerbalance.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey’s Latest News | Go to https://daveasprey.com/ to join Inside Track today.
Thank you to our sponsors!
– Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
– Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee.
– The One Device | Use code DAVE for $10 off at theonedevice.com/dave
– Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off.
Timestamps:
0:00 – Trailer
1:15 – Introduction
2:43 – The Gender Gap in Hormone Care
5:14 – Why Women’s Hormone Therapy Is Stuck in the 1960s
8:09 – Why Young Women Are Losing Their Hormones
9:33 – Toxins, Birth Control & Hormone Disruption
14:07 – How Fiber Steals Your Hormones
19:53 – Hormones, Libido & Brain Chemistry
32:13 – Pills, Patches & Why They Fail
36:54 – Why Vaginal Delivery Works Best
44:36 – Symptoms of Low Hormones
47:38 – How Low Hormones Destroy Relationships
52:28 – Thyroid, Iodine & Sex Hormones
1:00:29 – Progesterone for Men
1:05:18 – Oxalates, Kidney Stones & Your Diet
1:11:13 – Where to Find Dr. Sarah
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave’s favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
