For decades, we were told that our DNA is a rigid blueprint, locking us into a predetermined fate of aging, disease, and cognitive decline. But what if you could rewrite the script—turning on powerful longevity genes while silencing the pathways that drive inflammation, Alzheimer’s, heart disease, and metabolic disorders?
Sharon Hausman-Cohen, physician, researcher, and genomics expert at IntellxxDNA, joins Dave Asprey to reveal the cutting-edge world of DNA-based biohacking—where genetic testing for longevity meets precision medicine. Forget generic risk factors—this is about personalized genomics that deliver actionable, customized strategies to optimize mitochondrial function, enhance brainpower, and extend healthspan.
Inside This Episode:
• Why your genes DON’T dictate your future—and how to use epigenetics and aging science to take control of your health.
• MTHFR, APOE4 & other ‘bad genes’—do they really put you at risk? Or can they be hacked for better brain function?
• The hidden genetic factors behind ADHD, depression, and anxiety—and the surprising way to fix them.
• How inflammation pathways accelerate aging—and the genetic blueprint to slow it down.
• Mitochondrial health optimization—why your energy and lifespan depend on these tiny cellular engines.
• CRISPR technology & gene therapy for longevity—can we actually edit genes to extend human lifespan?
• How biohacking with genetic testing can help prevent Alzheimer’s, heart disease, and metabolic disorders—before symptoms even begin.
This isn’t science fiction—it’s the future of medicine. Your genetic code isn’t fixed—it’s an instruction manual you can tweak, upgrade, and optimize. The right knowledge lets you activate your strongest genetic potential, reduce disease risk, and enhance performance at every level.
Stop guessing. Start biohacking your DNA for peak longevity, energy, and cognition—today.
** Visit IntellxxDNA at https://intellxxdna.com/asprey/ When you go to the website to find a clinician please select “human upgrade/longevity” as the type of consult to get specialized biohacking clinicians! **
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• IntellxxDNA Website: https://intellxxdna.com/asprey/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Intro
• 02:00 – The Role of Genetics in Longevity
• 03:37 – Gene Variants & Cognitive Health
• 05:58 – Epigenetics vs. Genetics
• 08:21 – Genomics & Pain Management
• 09:26 – Breakthroughs in Genetic Research
• 12:33 – The Future of Genomic Medicine
• 14:27 – How to Use Genomic Reports
• 38:25 – Mitochondria & Longevity
• 42:40 – BH4 & Mental Health
• 43:42 – Folinic Acid & Brain Function
• 44:37 – Genomics & Autism
• 46:06 – Personalized Medicine
• 56:00 – APOE4 & Alzheimer’s Risk
• 59:44 – Genetics & Heart Health
• 01:04:54 – The Future of Precision Medicine
• 01:20:23 – Conclusion & Next Steps
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
