Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, mood, and longevity.
Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a pioneer in the next evolution of natural nootropics for focus, stress resilience, and sustainable energy. With a background in data-driven wellness, Jeff has spent over a decade helping high performers regulate the nervous system, sharpen cognition, and increase resilience without relying on caffeine, sugar, or synthetic stimulants. His approach merges functional medicine, self-quantification, and wellness rituals for high performers.
Together, they explore why 85% of supplements fail, how poor formulation creates “expensive pee,” and what actually works to support mitochondria, emotional balance, and long-term human performance. You’ll learn how adaptogens like saffron, L-theanine, and GABA can dramatically impact mood, clarity, and even high blood pressure naturally. They also cover how to optimize supplement timing around fasting, circadian rhythm, and ketosis to maximize results.
Whether you’re an entrepreneur facing burnout, a parent juggling demands, or a biohacking stress veteran looking to fine-tune your stack, this episode delivers the tools to enhance focus, balance neurotransmitters, and build lasting resilience from the inside out.
You’ll Learn:
• The real reason most supplements don’t absorb and how to fix it
• How to build a caffeine-free stack for energy, clarity, and mood
• The best adaptogens for stress, including saffron for mood and L-theanine/GABA effects
• How to align supplements with fasting and circadian biology
• Why “clean labels” can be misleading
• How to regulate your nervous system and prevent burnout
• Natural cognitive enhancers that actually work
This is essential listening for anyone serious about biohacking stress, longevity, natural nootropics, mitochondrial health, sleep optimization, entrepreneur mental health, and conscious human performance.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• MTE website – www.getmte.com
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:13 Saffron Benefits
• 02:26 Medicinal Herbs
• 04:12 Supplement Formulation
• 13:16 Theanine & GABA
• 20:06 Adaptogens & Performance
• 23:23 Stress & Muscle Growth
• 24:03 Parenting & Energy
• 27:47 Nervous System for Kids
• 35:15 Sleep for Families
• 36:41 Wrap-Up & Offers
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
