Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked tools in mitochondrial biohacking. This episode reveals how just 15 minutes of exercise with oxygen therapy (EWOT) can radically improve metabolism, enhance brain optimization, and even reverse chronic illness, without expensive gear, complex protocols, or clinic-only treatments.
Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, an affordable oxygen therapy solution designed for daily home use. After nearly dying from autoimmune conditions and the side effects of immune-suppressing drugs, Brad engineered his way out using high-dose oxygen therapy for chronic illness. His story is a case study in resilience, innovation, and what’s possible when you hack biology at the mitochondrial level.
You’ll learn:
• How oxygen therapy works differently from hyperbaric chambers and why it’s faster and more accessible
• Why inflammation and oxygen are biologically inseparable, and how oxygen restores cellular function
• How to detox with oxygen therapy and activate mitochondrial healing at scale
• When and how to stack EWOT with red light therapy, ketosis, nootropics, and supplements for maximum effect
• Why elite athletes and chronically ill patients are turning to oxygen-based protocols for faster results
• How to use EWOT as a daily tool in your “Smarter Not Harder” biohacking stack
This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, supplements, fasting, and long-term longevity.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Get a free Ebook on EWOT to learn more today:
https://cdn.shopify.com/s/files/1/0097/3186/6683/files/The_Oxygen_Advantage_Protocol_-_EWOT.pdf?v=1752173567
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• One Thousand Roads Website: http://onethousandroads.com/
• One Thousand Roads YouTube (more info on EWOT) : https://www.youtube.com/@OneThousandRoadsHQ
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Labs: https://upgradelabs.com
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Introduction
• 02:38 Discovering EWOT
• 03:55 Autoimmune Breakdown
• 06:54 Building One Thousand Roads
• 15:00 EWOT Science & Benefits
• 20:54 Protocols & Use Cases
• 29:03 Real-World Results
• 30:11 Brain Fog & Oxygen
• 30:58 Athletic Performance
• 31:41 Therapy Stacking
• 34:44 Mitochondria & Aging
• 37:08 Research & Studies
• 40:00 Future of Oxygen Therapy
• 43:02 Practical Tips & Access
• 51:09 Final Takeaways
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
