The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena)
Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your hormones, and your longevity.
Host Dave Asprey sits down with Regena Thomashauer, known worldwide as Mama Gena, founder and CEO of the School of Womanly Arts and a New York Times bestselling author. For over three decades she has taught hundreds of thousands of women how to reclaim pleasure as a source of power, and her work has redefined what modern feminism and embodiment look like in practice.
Dave and Regena break down the actual biology behind orgasm: the oxytocin, prolactin, and endorphin cascade that shifts the body out of fight or flight and into repair, the role of sleep optimization in processing trauma, and how chronic disconnection from pleasure keeps people stuck in survival mode instead of human performance mode. They dig into semen retention research and its link to longevity and anti-aging, why shame around the body blocks neuroplasticity and emotional healing, and how learning to regulate arousal, rage, and surrender is its own form of nervous system hacking. This is a masterclass in reclaiming a part of your biology most people were never taught to understand, let alone optimize.
This is essential listening for anyone serious about biohacking, human performance, brain optimization, functional medicine, longevity, and building a body and mind that can hold more pleasure, more power, and more presence.
You’ll Learn:
-How orgasm triggers an oxytocin, prolactin, and endorphin cascade that lowers cortisol and drives real nervous system repair
-Why the Daoist approach to semen retention is tied to longevity and anti-aging in men
-How chronic shame and disconnection from the body block neuroplasticity and keep trauma stuck
-The link between sleep optimization, hormone regulation, and processing deep emotional wounds
-How to move rage and grief through the body instead of suppressing them
-Why relaxation, not effort, is the real key to expanding pleasure and human performance
-How devotional presence between partners creates measurable shifts in nervous system state
Resources:
• Order Regena’s New Book On Our Knee’s and visit her website at: https://mamagenas.com/books/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
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Thank you to our sponsors!
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Timestamps:
00:00 – Trailer
01:21 –Intro
07:24 – Orgasm saved my life
16:34 – The body’s medicine cabinet
20:08 – Meaning of On Our Knees
27:34 – Betrayal and forgiveness
37:05 – Righteous anger vs. stridence
47:02 – Semen retention practice
52:51 – Energetic heart connection
01:00:53 – Daoist orgasm equations
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Danger Coffee: https://dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave’s favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
