In this Huberman Lab Essentials episode, my guest is Dr. Oded Rechavi, a professor at Tel Aviv University who studies genetics, epigenetics and the inheritance of acquired traits. We discuss how DNA, RNA and epigenetic mechanisms determine what information can pass between generations, and why acquired traits are generally not thought to be inherited. We also explain research in C. elegans showing how small RNAs can transmit antiviral resistance and influence behavior across generations, what these findings might mean for mammals and humans, and potential future applications for reproductive health and diagnostics.
Show notes: https://go.hubermanlab.com/HbTfdok
Full episode with Dr. Oded Rechavi: https://youtu.be/CDUetQMKM6g
Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5
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Timestamps
00:00:00 Oded Rechavi
00:00:24 DNA, Genome, RNA & Proteins
00:03:43 Somatic vs. Germ Cells; Inheritance
00:06:04 Lamarck vs. Darwin, Inheritance of Acquired Traits
00:08:27 Weismann Barrier, Epigenetic Reprogramming
00:11:46 RNA & Transgenerational Inheritance
00:12:35 Model Organisms, C. elegans
00:15:40 Inheritance of Acquired Traits in C. elegans
00:16:03 RNA Interference, Small RNAs & Gene Silencing
00:20:08 Viral Resistance Across Generations
00:22:15 Small RNAs, Mammals & Inherited Effects
00:23:23 Brain Activity, Memory & Heritable Information
00:26:09 Neuronal Small RNAs & Behavior Across Generations
00:27:22 Germ Cells, Development & Heritable RNA
00:29:01 Future Applications, Exercise, IVF & RNA Diagnostics
00:31:06 Acknowledgements
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Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer
