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How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting Easier
Host Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower.
The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer. Originally investigated through a multimillion-dollar research program, this bitter plant extract activates specialized receptors in the digestive tract that stimulate the body’s natural appetite-regulating hormones. Sarah explains how this discovery led to Calocurb, a supplement designed to reduce hunger, control cravings, and make fasting and calorie restriction easier.
Dave and Sarah break down the biology of GLP-1, CCK, PYY, ghrelin, and leptin, exploring how these hormones influence hunger, fullness, food cravings, and metabolic health. Unlike injectable GLP-1 medications such as Ozempic and Wegovy, Amarasate works through bitter taste receptors in the gut to stimulate the body’s own satiety signaling. They examine why the timing and location of these signals matter, how quickly the extract begins working, and what distinguishes this approach from conventional appetite suppressants.
They also explore how hops extract may make intermittent fasting and extended fasting easier by reducing hunger and food cravings. Dave discusses the practical challenges of fasting, while Sarah explains how bitter receptor activation can help people manage appetite without constantly fighting the urge to eat. They examine the potential applications for time-restricted eating, longer fasting windows, calorie control, and sustainable weight management.
You’ll Learn:
-How a patented compound extracted from hops activates bitter receptors in the gut to stimulate GLP-1, CCK, and PYY, the hormones involved in hunger and fullness
-Why clinical research found that hops extract reduced calorie intake by approximately 18%, and what that means for appetite control and overeating
-How a six-month clinical trial reported 5.5% body-weight loss, reduced visceral fat, and no detected average muscle loss
-Why hunger, cravings, and overeating involve complex hormonal signaling rather than simply a lack of willpower
-How natural appetite regulation may make intermittent fasting, extended fasting, and calorie restriction easier to maintain
-How hops-derived compounds differ from injectable GLP-1 medications, and what the research suggests about their potential role in weight management
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
Resources:
• Calocurb Discount | Use ‘Dave10’ at calocurb.com on your next purchase!
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
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• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
– Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.
– ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
– Mars Men | For a limited time, our listeners get 50% off FOR LIFE, Free Shipping, AND 3 Free Gifts at Mars Men at Mengotomars.com.
– Neuronic | Go to www.neuronic.online Code DAVE for $100 off
Timestamps:
00:00 – Trailer
01:32 – Intro
03:06 – Discovering Hops Extract
07:58 – Finding the Right Hop
10:15 – Clinical Trial Results
15:34 – No Rebound Weight Gain
19:47 – Personal Story & Fasting
23:05 – Women’s Fasting Study
29:32 – Willpower & Hunger
38:42 – Combining With GLP-1s
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