What if mitochondria didn’t just power your body—but acted as conscious beings guiding your survival, consciousness, and evolution?
In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of human health and consciousness. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape perception, drive healing, and accelerate human evolution.
You’ll discover how chronic disease, fatigue, brain fog, and emotional trauma often trace back to broken cellular communication—and how restoring that internal network unlocks radical resilience, deeper energy, and true longevity.
Through the lens of regenerative health, soil microbiome collapse, glyphosate’s role in chronic disease, vibrational biology, light frequencies, sacred geometry biology, and ancient microbial wisdom, Zach Bush shows why the future of biohacking demands reconnection to the deeper intelligence already alive inside you.
Along the way, you’ll explore the emerging science of exosomes vs. viruses, the link between mitochondrial intelligence and consciousness, and how practices like ION* Gut Therapy, Power of Eight group dynamics, and non-dual science spirituality reshape human potential.
What You’ll Learn in This Episode:
• How mitochondria act as conscious messengers—not just energy factories—and why that transforms health, consciousness, and aging
• How rebuilding gut microbiome intelligence strengthens immune function, brain health, emotional resilience, and vitality
• How broken cellular communication fuels glyphosate-driven chronic disease, autoimmune conditions, and early aging
• How emotional trauma imprints onto genetic expression and triggers mitochondrial collapse
• How viruses and exosomes serve as evolutionary communication networks—not biological threats
• How “cellular safety” drives healing, regeneration, and peak human performance
• How carbon cycles, soil health, and light frequencies repair DNA and extend human lifespan
• How sacred geometry biology and Power of Eight fields accelerate collective healing
• Simple daily practices that rebuild cellular coherence, optimize mitochondrial function, and reconnect you to innate intelligence
This conversation will rewire how you think about human health, the microbiome, mitochondria, consciousness, and the true nature of disease—and give you the tools to upgrade your biology, mind, and spirit at the deepest level.
**Check out Zach’s exclusive offer for The Human Upgrade listeners at https://intelligenceofnature.com/ and use code ‘DAVE10” for a discount!**
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Zach’s Website – https://zachbushmd.com/
• Zach’s Instagram – https://www.instagram.com/zachbushmd/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:52 Intro: Microbiome and Human Connection
• 03:07 Microbiome’s Role in Nutrition and Health
• 05:48 Chemical Farming’s Impact on Soil and Health
• 09:23 Mitochondria and Cellular Communication
• 26:00 Viruses, Exosomes, and Evolution
• 34:36 The Observer Effect and Reality
• 40:08 Tech vs. Nature in Healing
• 41:04 Light, Mitochondria, and Cellular Energy
• 42:01 Choosing Tech or Natural Regeneration
• 43:44 The Miracle of Life and Human Potential
• 45:05 Healing Generational Trauma
• 47:38 Shamanic States and Connection
• 01:05:48 Sacred Geometry and Group Healing
• 01:12:48 Rational vs. Mystical Perspectives
• 01:14:52 Finding Common Ground
• 01:15:10 Inside the Supplement Room
• 01:15:47 Emerging Tech in Biohacking
• 01:15:58 Non-Tech Health Upgrades
• 01:16:11 Stem Cell Concerns and Cautions
• 01:17:31 Nature Deficit and Health Impacts
• 01:19:09 Curiosity and Personal Growth
• 01:20:56 Generational Shifts and Gender
• 01:24:20 Strengthening Relationships Through Differences
• 01:28:31 Storytelling’s Power Over Data
• 01:38:24 Longevity and Embracing Elderhood
• 01:44:47 Final Thoughts and Future Visions
Connect with Dave Asprey!
Website: https://daveasprey.com
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