Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking toxins, resilience, and smarter detox strategies from two experts who’ve spent decades researching how to upgrade the human body.
Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, exposed the dangers of PFAS water contamination, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance.
Together, they break down:
• How rare plant compounds like Osmotin support adiponectin benefits and mitochondrial repair
• Why PFAS, fragrance chemicals, and EMFs are silently undermining your biology
• How everyday products like dental floss, plastic bottles, and synthetic clothing create hidden toxicity
• What makes tap water unsafe, the difference between reverse osmosis vs distillation, and how to protect your home
• The truth about endocrine disruptors in common spaces like your bathroom, your laundry, and even your Uber
• How adaptogens for longevity can regulate stress and support deep cellular healing
• Natural tools to detox heavy metals and activate your own stem cell repair system
• The role of air quality, light, and toxic household products in aging, energy, and mood
This episode delivers actionable tools to build a cleaner body, sharper mind, and longer life. You’ll also gain insight into the broken systems that allow chemical exposure to thrive and how personal awareness can drive systemic change.
If you’re exploring senolytics, sleep optimization, neurohacking, or smarter ways to upgrade your environment, those topics are covered extensively throughout this channel.
Whether you’re eliminating hidden toxins or optimizing with Danger Coffee, this conversation reflects the core mission of Smarter Not Harder and the innovation behind Upgrade Labs.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, nootropics, nutrition, detox, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave Asprey asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Darin’s Website – https://superlife.com/
• Darin’s Instagram: https://www.instagram.com/darinolien/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Intro
• 02:14 Meet Darin Olien
• 04:26 Wildfires and Pollution
• 07:13 PFAS and Everyday Toxins
• 12:37 Corporate and Regulatory Failure
• 26:36 Synthetic Fragrances
• 36:12 Water and Air Filtration
• 36:53 Indoor Air Quality
• 38:33 Building Healthy Habits
• 40:05 Essential Oils and Hormones
• 41:54 Tofu, Tempeh, and Estrogen
• 46:34 Adiponectin and Biohacking
• 47:04 Osmotin for Longevity
• 49:48 Stem Cells and Repair
• 53:57 Communicating Science
• 01:04:12 Nutrition and the Microbiome
• 01:06:14 Final Thoughts
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
