For years, gut health was dismissed as hype—sold in yogurt ads and overpriced probiotics that never made it past your stomach acid. But what if the real reason you’re tired, inflamed, and foggy isn’t in your head… it’s in your gut microbiome?
In this riveting episode, Dave Asprey sits down with Hannah Kleinfeld, a leader in microbiome therapeutics, to reveal the truth behind gut disruption caused by antibiotic use, glyphosate in food, and even popular GLP-1 weight-loss drugs. From her own battle with Lyme disease and leaky gut to launching a precision probiotic platform backed by human clinical trials, Hannah delivers science-backed insights that may radically change how you think about your brain, mood, and metabolism.
You’ll learn why brain fog, metabolic dysfunction, and mood swings may actually begin in your gut—and how to reset your system with the right mix of probiotics, prebiotics, postbiotics, and synbiotics. This goes way beyond digestion: your gut is making decisions for you, every day.
So how do you take back control—from SIBO treatment to repairing secondary dysbiosis triggered by modern living?
What You’ll Learn in This Episode:
• Why your gut—not your brain—is driving your cravings, sleep, and stress
• How 93% of probiotics fail due to poor delivery and survive rates
• The “AB 10” protocol that rebuilds your microbiome post-antibiotics or SIBO
• How GLP-1 drugs can cause long-term gut bacteria imbalances
• The surprising gut–brain–heart axis and what it means for emotional health
• How leaky gut drives inflammation, anxiety, and cognitive decline
• Which targeted strains improve cognition, mood, and gut-brain signaling
• Why AI gut microbiome analysis is changing personalized gut care
• How to eat gluten again—or at least survive American wheat
• Why a fermented papaya concentrate may outperform acid reflux meds
• How optimizing your gut could extend your life by up to 40%
***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• OMNi-BiOTiC’s Instagram – https://www.instagram.com/fatty15/
• OMNi-BiOTiC’s Website: https://omnibioticlife.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 03:15 – Intro
• 05:05 – Probiotics, Prebiotics, and Postbiotics Explained
• 08:21 – The Importance of Delivery Mechanisms
• 17:36 – Addressing SIBO and Gut Health Protocols
• 31:55 – The Impact of GLP-1 Drugs on Gut Health
• 39:26 – The Role of Gut Bacteria in Hunger and Fasting
• 40:01 – Painkillers and Gut Health: A Personal Experience
• 40:51 – The Dangers of Proton Pump Inhibitors
• 42:00 – The Importance of Stomach Acid
• 44:55 – Probiotics for Chronic Conditions
• 48:38 – The Impact of Glyphosate on Gut Health
• 57:04 – Alcohol and Gut Bacteria
• 01:02:01 – New Solutions for Acid Reflux
• 01:07:57 – The Future of Gut Health and Longevity
• 01:11:33 – Conclusion and Special Offer
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
