Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products like vitamin C serums, harsh exfoliants, and even blue light therapies can disrupt mitochondria skin health, accelerate senescent cells in the skin, and trigger systemic inflammation. You’ll learn how to reverse this damage using biohacking skincare principles, supporting topical autophagy, enhancing structured water skin effects, and rebuilding a resilient skin barrier that slows aging at the cellular level.
Host Dave Asprey sits down with Amitay Eshel, a pioneer in biohacking skincare and founder of Young Goose skincare. With expertise in regenerative aesthetics, Amitay applies cutting-edge tools like NAD skin benefits, spermidine for skin, and fat-soluble vitamin C (including THD ascorbate) to tackle the root causes of aging. You’ll discover how ingredients like ectoine UV protection, tardigrade skincare ingredient derivatives, and CD38 and NAD depletion inhibitors drive better results than conventional clean beauty products.
This conversation connects skin brain axis science to your daily routine, showing how old skin can lead to an inflamed brain and why your skincare choices directly affect cognition, mood, and longevity. You’ll also learn how red light therapy face protocols, Upgrade Labs-style recovery, fasting, and structured water formulations enhance the skin’s mitochondrial performance from the outside in.
This is a masterclass in smarter, not harder skincare, blending anti-aging biohacks, mitochondria support, and clean beauty vs biohacking science into one routine that improves both appearance and biology.
You’ll learn:
• Which popular skincare trends cause long-term mitochondrial damage
• How topical NAD and spermidine extend youthful skin function
• The link between senescent cells skin burden and brain inflammation
• How to support skin barrier repair and boost autophagy
• What structured water, red light therapy, and cold therapy do for collagen and elastin
• Why your skin is the ultimate self-quantification tool for internal health
• The performance benefits of smarter formulations backed by science and biohacking
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to control their biology, extend longevity, and optimize mind-body performance.
Episodes air Tuesdays and Thursdays, where Dave goes deeper than anyone else to bring you the tools to become truly resilient, conscious, and high-performing.
Resources:
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Young Goose Website – https://www.younggoose.com/ and use code “Dave10” at checkout to get a discount!
• Young Goose Instagram: https://www.instagram.com/young_goose_skincare/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 00:52 – Intro
• 01:27 – Anti-Aging Mistakes
• 05:20 – Skin Recovery Science
• 07:44 – NAD & Mitochondria
• 08:52 – Autophagy Compounds
• 12:06 – Sleep & Topicals
• 18:36 – Overtraining Effects
• 21:07 – Vitamin C & Antioxidants
• 28:48 – Breakthrough Formulations
• 35:50 – Tallow vs. MCT
• 36:11 – Sun & Longevity
• 37:28 – Red Light Therapy
• 40:12 – UV Light Benefits
• 42:18 – Advanced Skincare Tech
• 48:48 – NAD Topicals
• 01:00:05 – Building Your Routine
• 01:07:39 – Final Takeaways
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
