Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You’ll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing.
Listen to the FULL-LENGTH version of this episode on your favorite audio platform:
-Apple: https://podcasts.apple.com/us/podcast/the-human-upgrade-biohacking-for-longevity-performance/id451295014
-Spotify: https://open.spotify.com/show/2mkB9OoukPVKCTKSuAIgCq
Host Dave Asprey sits down with Len May, MSc, visionary authority in personalized medicine and CEO of EndoDNA, the world leader in DNA-based wellness technology. With over 25 years of pioneering work in genomics, epigenetics, and medicinal cannabis, Len’s patented DNA decoding system maps your unique genotypes to design tailor-made health solutions. His company holds the world’s largest real-world efficacy database in precision wellness, integrating functional medicine, AI-driven analytics, and genetic data to create personalized blueprints for optimal brain function and performance.
Together, Dave and Len explore how your genetic code determines how you respond to cannabis, psychedelics, nootropics, and supplements—and how to use that data to reduce anxiety, improve sleep optimization, and enhance focus. You’ll learn how decoding your DNA can guide anti-aging strategies, mitochondrial performance, metabolism, and neuroplasticity, revealing new ways to live longer and smarter.
You’ll Learn:
• How the endocannabinoid system regulates mood, focus, pain, and stress response
• Which genetic polymorphisms affect cannabis sensitivity, anxiety risk, and dosing windows
• How to use DNA testing to select cannabinoid and terpene ratios that fit your biology
• Why delivery method matters and when sublingual dosing outperforms inhalation
• How personalized cannabis protocols can support sleep optimization, recovery, and emotional regulation
• The role of cannabinoids in mitochondrial function, neuroplasticity, and cognitive performance
• How pharmacogenomics reduces antidepressant side effects and improves treatment matching
• How to screen genetics for safer psychedelic use and avoid adverse reactions
• What HLA and related markers reveal about mold sensitivity and inflammation
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Thank you to our sponsors!
-Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.
-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
-iRestore | Use code DAVE at https://www.irestore.com/ to unlock an exclusive discount on the iRestore Elite.
Timestamps:
0:00 — Trailer
1:25 — Introduction
8:14 — Cannabis, Terpenes & Brain Health
11:44 — Psychedelics & Genetic Testing
17:13 — Pharmacogenomics & Drug Safety
22:38 — Life-Changing Cannabis Stories
28:24 — Precision Medicine & Consistency
31:59 — GLP-1 Agonists & Weight Loss
35:06 — Genetic Testing for Everyone
38:35 — Microbiome Testing & Personalized Nutrition
40:00 — Final Thoughts
Learn more about Len’s work at www.EndoDNA.com and use code ‘LEN25’ for a discount.
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Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave’s favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Collective: https://www.ourupgradecollective.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
