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    Home » How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague

    How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague

    Mal AntoniBy Mal AntoniFebruary 2, 2026 All Videos 2 Mins Read
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    Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain.

    Full show notes and resources: https://go.hubermanlab.com/CgI5pMA

    *Thank you to our sponsors*
    AG1: ⁠https://drinkag1.com/huberman
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    *Timestamps*
    00:00:00 Read Montague
    00:02:54 Dopamine, Motivation & Learning
    00:08:49 Reward Prediction Error, Expectations
    00:12:24 Sponsors: David & Joovv
    00:14:54 Foraging, Dating, Expectations vs Outcomes; AI
    00:23:36 Dopamine, Expectation, Motivation; Forward Drive; Dopamine “Hits”
    00:29:58 Baseline Dopamine & Fluctuations; Parkinson’s Disease
    00:34:36 Movement, Urgency; ADHD, Bee’s Dance, Explorer vs Focus Mode
    00:42:29 Sponsor: AG1
    00:43:40 Social Media, ADHD; Explorers vs Task-Based, Combat
    00:50:54 Effort, Learning; Social Media & Phones, Resisting Behaviors
    01:01:36 Serotonin & Dopamine, Opponency, SSRIs
    01:11:21 Hunger, Dopamine; Negative Feedback, Learning, Trauma; Torture
    01:18:34 Drugs of Abuse & High Dopamine
    01:19:48 Sponsor: Function
    01:21:35 Trauma & Dopamine Adaptation
    01:27:34 SSRIs, Dopamine, Positive Experiences
    01:29:50 Deep Brain Stimulation; Measuring Dopamine & Serotonin in Humans
    01:36:16 Sleep; Divorce; Science is a Contact Sport
    01:45:14 Long-Term Motivation, Learning How to Fail, Tool: Kids & Sports
    01:54:14 Sponsor: LMNT
    01:55:34 Meditation, Breathing, Learning; Dopamine as a Currency
    02:04:38 Function of Sleep, Motivation; Time Perception & Dopamine, Tracking Time
    02:13:18 LLMs, AI, Uses & Problem Solving
    02:18:33 Future Projects, Commercial Brain-Machine Interfaces; Concentration
    02:25:57 Dopamine “Hits”?; Depression & Schizophrenia; Quitting
    02:30:17 Dopamine & Serotonin Misunderstandings; Internal Satisfaction; Motivation
    02:35:58 Serotonin Syndrome; Acknowledgements
    02:38:31 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

    #HubermanLab #Science #Dopamine #Serotonin #Learning

    ⁠Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

    Mal Antoni

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