Mark Sisson was a competitive runner, appeared on the cover of Runner’s World three times, and trained up to 130 miles in a single week. He tells Dr. Gundry that most of what he thought he knew about exercise and longevity turned out to be working against him.
Mark Sisson is a New York Times bestselling author and the co-founder of the barefoot shoe company Peluva. Today he’s back with his latest book,
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Dr. Gundry sits down with Mark Sisson, founder of Mark’s Daily Apple and the Primal Blueprint movement, to unpack something most people don’t realize: how much influence you actually have over your own genetic switches. They dig into what Mark calls the hidden power everyone has to turn on genes that build muscle and burn fat, and turn off the ones that drive aging, based on daily choices most people never think twice about.
The conversation goes deep into Mark’s own personal story, including why he says most people are better off walking than running, and why he believes the past 50 years of running culture got some fundamental things wrong. They also cover the surprising history behind modern running shoes, how Mark defines longevity through mobility and cognition rather than just lifespan, and the specific footwear shift he made after decades of injuries.
Whether you’re focused on longevity, movement, or just trying to understand what’s actually in your control as you age, this conversation reframes the whole conversation.
00:00 – The Running Boom Is Over
00:46 – Why He Quit Running Despite Being Elite
07:57 – The Case For Walking Over Running
13:54 – The Power Of Exercise Snacking
19:41 – The Diabetic Researcher Who Reversed Course
27:14 – What The Shoe Industry Got Wrong
33:33 – Why He Built His Own Shoe
43:04 – The Big Toe-Brain Connection
44:18 – Final Takeaway And Audience Question
#MarkSisson #DrGundry #Longevity #Epigenetics #BornToWalk #Aging #Mobility #PrimalBlueprint #paluva #paluvashoes
