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The Science of Reversing Biological Age with Dr. Tim Cook
Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two Governors General of Canada, to explore experimental gene therapy, biological age reversal, stem cell re-education, immune rejuvenation, muscle growth, and the emerging science of extending human lifespan.
Recorded in the Amazon rainforest in Ecuador, the conversation explores three advanced longevity treatments Dave and Tim are working with through House of Evolution, their venture focused on expanding access to experimental therapies. They discuss how these technologies work, the early results they’re observing, and why some treatments are currently available outside the United States.
The discussion turns to follistatin gene therapy, an experimental treatment designed to increase a protein involved in muscle growth and maintenance. Dave and Tim share preliminary results, including a reported average nine-year reduction in biological-age measurements, increased lean muscle mass, and reductions in body fat. They examine why preserving muscle and reducing visceral fat may be critical for longevity, particularly as anabolic resistance and sarcopenia become more common with age.
This episode is essential listening for anyone interested in biological age reversal, gene therapy, follistatin, klotho, stem cell re-education, immune rejuvenation, autoimmune disease, muscle growth, visceral fat, regenerative medicine, longevity escape velocity, and the future of anti-aging medicine.
You’ll Learn:
-How Dave’s two-day stem cell re-education treatment was followed by a reported 15.2-year reduction in his measured immune age, and how the procedure works
-Why follistatin gene therapy is being investigated for muscle growth, sarcopenia, body composition, and biological aging
-How experimental plasmid-based gene therapies increase protein production without intentionally editing the human genome
-What early klotho gene therapy results suggest about protein levels, cognitive performance, kidney health, and longevity
-How stem cell banking, cellular reprogramming, and regenerative medicine could shape the future of longevity treatments
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
Resources:
• The House of Evolution is A members-only longevity community combining gene expression therapy, stem cell therapy, and small-group experiences in destinations around the world. Apply here https://daveasprey.com/house-of-evolution/
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Timestamps:
00:00 — Trailer
00:59 — Follistatin Gene Therapy
05:25 — How Plasmids Work
09:30 — Longevity Escape Velocity
16:30 — Follistatin Results & Data
21:30 — Klotho: The Cognitive Protein
24:30 — House of Evolution
30:30 — Stem Cell Re-Education
39:00 — Stem Cell Banking
41:30 — The Future of Longevity
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