Visit https://loveyourliver.com and use code DAVE7 to access the special offer from de-liver-ance mentioned in this episode.
Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity
Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity.
Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis.
Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver.
The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process.
This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking.
You’ll Learn:
-Why fatty liver can develop even in people who are thin or rarely drink alcohol
-Why normal bloodwork may not always reveal what is happening inside the liver
-How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function
-What rapid weight loss and GLP-1 use may mean for liver function
-How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health
-Why liver scans, nutrition, and supplement quality may matter for long-term health
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the founder of biohacking. With over 1,000 interviews and 1 million monthly listeners, The -Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Resources:
• Visit LoveYourLiver.com and use code DAVE7 to access the special offer from de-liver-ance mentioned in this episode.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey’s Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
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– BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.
Timestamps:
00:00 — Trailer
01:00 — Liver Basics & Signs
05:30 — Liver Scan Technology
08:15 — Chemicals & Liver Disease
11:30 — Deliverance Formula Story
17:15 — Estrogen, Alcohol & HRT
22:30 — GLP-1s & Liver Toxicity
28:00 — Bile & Gut Health
33:10 — Chimerism & Transplants
41:30 — Hormesis & Painkillers
50:00 — Sweeteners, Hormones & Thyroid
55:00 — Outro – Discount
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